Codexis Inc

Codexis Inc builds enzymes on purpose. Founded in 2002 and headquartered in Redwood City, California, the company uses proprietary protein engineering to design biocatalysts for small molecule pharmaceuticals manufacturing, nucleic acid synthesis, and RNA production - work that sits at the intersection of molecular biology, genomics, and diagnostics. The core engine is CodeEvolver®, a directed-evolution platform for discovering and optimizing novel enzymes and other protein classes.

The applied work spans several fronts. Pharma biocatalysis replaces resource-intensive chemical routes with enzymatic ones and scales from grams to tons. RNA manufacturing services use enzyme-enabled processes to deliver higher yield and quality than traditional chemistry. The molecular biology and diagnostics unit tunes enzymes for improved fidelity, enhanced selectivity, and increased activity. In development is ECO Synthesis™, a manufacturing platform intended to scale RNAi therapeutics through an enzymatic route rather than a chemical one.

For technical candidates, the environment is one where the assets are process know-how, sequence and construct data, and manufacturing IP across pharmaceuticals, biopharmaceuticals, and industrial biotechnology verticals. The stated operating priorities are scalability and sustainability - higher yields with reduced energy use and waste generation. Details at https://codexis.com/.